60-second answer
Break-even ACoS equals contribution before ads as a share of sales.
Subtract product cost, fulfillment, marketplace and payment fees, expected returns, and other variable seller costs from the attributed sales basis. Divide the remaining contribution by that same sales basis.
Break-even ACoS % = contribution before ads / attributed sales
Target ACoS % = (contribution before ads - retained profit) / attributed sales
ROAS is the reciprocal: a 25% target ACoS equals 4.00x target ROAS.